Lady Montagu and the Smallpox Gamble

In the early eighteenth century, smallpox was one of the most feared diseases in Europe. It killed around three in every ten people it infected and left many survivors scarred or blind. Lady Mary Wortley Montagu knew its cruelty personally: the disease had killed her brother and marked her own face. In 1717, while living in Constantinople (now Istanbul), where her husband was the British ambassador, she observed a remarkable practice. Local women would take a small amount of material from a mild smallpox sore and scratch it into the skin of a healthy person. The person usually developed a mild illness and was then protected for life. This process was called variolation. Montagu was so impressed that she had her young son variolated. When she returned to England, she campaigned to spread the practice, despite fierce opposition. Some doctors resented being taught by a woman; others distrusted a practice from abroad. To win public confidence, Montagu had her daughter variolated in front of physicians from the royal court. Variolation was not without risk: a small number of patients developed severe smallpox, and they could infect others. Decades later, in 1796, Edward Jenner developed a safer method using cowpox, a related but much milder disease. His method, called vaccination after the Latin word for cow, gradually replaced variolation. Smallpox was declared eradicated worldwide in 1980. Jenner is often called the father of vaccination, but the story began with the courage of a woman who noticed what others had overlooked.